Symptoms & Info

Brain Aneurysm Basics That Can Save Your Life, from the Brain Aneurysm Foundation.

What Is A Brain Aneurysm?
A brain aneurysm is a weak bulging spot on the wall of a brain artery, very much like a thin balloon or weak spot on an inner tube.

Brain Aneurysm Statistics

  • An estimated 6 million people in the United States have an unruptured brain aneurysm, or 1 in 50 people.
  • The annual rate of rupture is approximately 8 per 100,000 people or about 30,000 people in the United States.
  • There is a brain aneurysm rupturing every 18 minutes.
  • There are almost 500,000 deaths worldwide each year caused by brain aneurysms and half the victims are younger than 50.
  • About 40% of all people who have a ruptured brain aneurysm will die as a result. Of those who survive, about 66% will suffer some permanent deficit.
  • 4 out of 7 people who recover from a ruptured brain aneurysm will have disabilities.
  • Brain aneurysms are most prevalent in people ages 35 – 60, but can occur in children as well.
  • Women, more than men, suffer from brain aneurysms at a ratio of 3:2.
  • Ruptured brain aneurysms account for 3 – 5% of all new strokes.

Warning Signs/Symptoms
Unruptured

  • Localized headache
  • Dilated pupil
  • Blurred or double vision
  • Pain above and behind the eye
  • Weakness and numbness
  • Difficulty speaking

Ruptured
Localized or diffuse headache associated with one
or more of the following:

  • Sudden severe headache, the worst headache of your life
  • Loss of consciousness
  • Nausea and vomiting
  • Stiff neck
  • Sudden blurred or double vision
  • Sudden pain above/behind the eye or difficulty seeing
  • Sudden change in mental status or awareness
  • Sudden trouble walking or dizziness
  • Sudden weakness and numbness
  • Sensitivity to light (photophobia)
  • Seizure
  • Drooping eyelid

Risk Factors that doctors and researchers believe contribute to the formation of brain aneurysms:

  • Smoking
  • High blood pressure or hypertension
  • Congenital resulting from inborn abnormality in artery wall
  • Family history of brain aneurysms
  • Age over 40
  • Gender, women compared with men have an increased incidence of aneurysms at a ratio of 3:2
  • Other disorders: Ehlers-Danlos Syndrome, Polycystic Kidney Disease, Marfan’s Syndrome, Fibromuscular Dysplasia(FMD)
  • Presence of an arteriovenous malformation (AVM)
  • Drug use, particularly cocaine
  • Infection
  • Tumors
  • Traumatic head injury

 

Source: National Institute of Neurological Disorders and Stroke

Brain aneurysms can occur in anyone, at any age.  They are more common in adults than in children and slightly more common in women than in men.  People with certain inherited disorders are also at higher risk.

How are cerebral aneurysms diagnosed?

Most cerebral aneurysms go unnoticed until they rupture or are detected by brain imaging that may have been obtained for another condition.  Several diagnostic methods are available to provide information about the aneurysm and the best form of treatment.  The tests are usually obtained after a subarachnoid hemorrhage, to confirm the diagnosis of an aneurysm.

Angiography is a dye test used to analyze the arteries or veins.  An intracerebral angiogram can detect the degree of narrowing or obstruction of an artery or blood vessel in the brain, head, or neck, and can identify changes in an artery or vein such as a weak spot like an aneurysm.  It is used to diagnose stroke and to precisely determine the location, size, and shape of a brain tumor, aneurysm, or blood vessel that has bled.  This test is usually performed in a hospital angiography suite.  Following the injection of a local anesthetic, a flexible catheter is inserted into an artery and threaded through the body to the affected artery.  A small amount of contrast dye (one that is highlighted on x-rays) is released into the bloodstream and allowed to travel into the head and neck.  A series of x-rays is taken and changes, if present, are noted.

Computed tomography (CT) of the head is a fast, painless, noninvasive diagnostic tool that can reveal the presence of a cerebral aneurysm and determine, for those aneurysms that have burst, if blood has leaked into the brain.  This is often the first diagnostic procedure ordered by a physician following suspected rupture.  X-rays of the head are processed by a computer as two-dimensional cross-sectional images, or “slices,” of the brain and skull.  Occasionally a contrast dye is injected into the bloodstream prior to scanning.  This process, called CT angiography, produces sharper, more detailed images of blood flow in the brain arteries.  CT is usually conducted at a testing facility or hospital outpatient setting.

Magnetic resonance imaging (MRI) uses computer-generated radio waves and a powerful magnetic field to produce detailed images of the brain and other body structures.  Magnetic resonance angiography (MRA) produces more detailed images of blood vessels.  The images may be seen as either three-dimensional pictures or two-dimensional cross-slices of the brain and vessels.  These painless, noninvasive procedures can show the size and shape of an unruptured aneurysm and can detect bleeding in the brain.

Cerebrospinal fluid analysis may be ordered if a ruptured aneurysm is suspected.  Following application of a local anesthetic, a small amount of this fluid (which protects the brain and spinal cord) is removed from the subarachnoid space — located between the spinal cord and the membranes that surround it—by surgical needle and tested to detect any bleeding or brain hemorrhage.  In individuals with suspected subarachnoid hemorrhage, this procedure is usually done in a hospital.

How are cerebral aneurysms treated?
Not all cerebral aneurysms burst.  Some people with very small aneurysms may be monitored to detect any growth or onset of symptoms and to ensure aggressive treatment of coexisting medical problems and risk factors.  Each case is unique, and considerations for treating an unruptured aneurysm include the type, size, and location of the aneurysm; risk of rupture; the individual’s age, health, and personal and family medical history; and risk of treatment.

Two surgical options are available for treating cerebral aneurysms, both of which carry some risk to the individual (such as possible damage to other blood vessels, the potential for aneurysm recurrence and rebleeding, and the risk of post-operative stroke).

Microvascular clipping involves cutting off the flow of blood to the aneurysm.  Under anesthesia, a section of the skull is removed and the aneurysm is located.  The neurosurgeon uses a microscope to isolate the blood vessel that feeds the aneurysm and places a small, metal, clothespin-like clip on the aneurysm’s neck, halting its blood supply.  The clip remains in the person and prevents the risk of future bleeding.  The piece of the skull is then replaced and the scalp is closed.  Clipping has been shown to be highly effective, depending on the location, shape, and size of the aneurysm.  In general, aneurysms that are completely clipped surgically do not return.

A related procedure is an occlusion, in which the surgeon clamps off (occludes) the entire artery that leads to the aneurysm.  This procedure is often performed when the aneurysm has damaged the artery.  An occlusion is sometimes accompanied by a bypass, in which a small blood vessel is surgically grafted to the brain artery, rerouting the flow of blood away from the section of the damaged artery.

Endovascular embolization is an alternative to surgery.  Once the individual has been anesthetized, the doctor inserts a hollow plastic tube (a catheter) into an artery (usually in the groin) and threads it, using angiography, through the body to the site of the aneurysm.  Using a guide wire, detachable coils (spirals of platinum wire) or small latex balloons are passed through the catheter and released into the aneurysm.  The coils or balloons fill the aneurysm, block it from circulation, and cause the blood to clot, which effectively destroys the aneurysm.  The procedure may need to be performed more than once during the person’s lifetime.

People who receive treatment for aneurysm must remain in bed until the bleeding stops.  Underlying conditions, such as high blood pressure, should be treated.  Other treatment for cerebral aneurysm is symptomatic and may include anticonvulsants to prevent seizures and analgesics to treat headache.  Vasospasm can be treated with calcium channel-blocking drugs and sedatives may be ordered if the person is restless.  A shunt may be surgically inserted into a ventricle several months following rupture if the buildup of cerebrospinal fluid is causing harmful pressure on surrounding tissue.  Individuals who have suffered a subarachnoid hemorrhage often need rehabilitative, speech, and occupational therapy to regain lost function and learn to cope with any permanent disability.

Can cerebral aneurysms be prevented?

There are no known ways to prevent a cerebral aneurysm from forming.  People with a diagnosed brain aneurysm should carefully control high blood pressure, stop smoking, and avoid cocaine use or other stimulant drugs.  They should also consult with a doctor about the benefits and risks of taking aspirin or other drugs that thin the blood.  Women should check with their doctors about the use of oral contraceptives.

What is the prognosis?
An unruptured aneurysm may go unnoticed throughout a person’s lifetime.  A burst aneurysm, however, may be fatal or could lead to hemorrhagic stroke, vasospasm (the leading cause of disability or death following a burst aneurysm), hydrocephalus, coma, or short-term and/or permanent brain damage.

The prognosis for persons whose aneurysm has burst is largely dependent on the age and general health of the individual, other preexisting neurological conditions, location of the aneurysm, extent of bleeding (and rebleeding), and time between rupture and medical attention.  It is estimated that about 40 percent of individuals whose aneurysm has ruptureddo not survive the first 24 hours; up to another 25 percent die from complications within 6 months.  People who experience subarachnoid hemorrhage may have permanent neurological damage.  Other individuals may recover with little or no neurological deficit.  Delayed complications from a burst aneurysm may include hydrocephalus and vasospasm.  Early diagnosis and treatment are important.

Individuals who receive treatment for an unruptured aneurysm generally require less rehabilitative therapy and recover more quickly than persons whose aneurysm has burst.  Recovery from treatment or rupture may take weeks to months.

Results of the International Subarachnoid Aneurysm Trial (ISAT), sponsored primarily by health ministries in the United Kingdom, France, and Canada and announced in October 2002, found that outcome for individuals who are treated with endovascular coiling may be superior in the short-term (1 year) to outcome for those whose aneurysm is treated with surgical clipping.  Long-term results of coiling procedures are unknown and investigators need to conduct more research on this topic, since some aneurysms can recur after coiling.  Individuals may want to consult a specialist in both endovascular and surgical repair of aneurysms, to help provide greater understanding of treatment options.

Source: National Institute of Neurological Disorders and Stroke

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